Daisy and Melinda escape the Triskelio and go on the run from Hydra. Meanwhile, Jemma realizes what Aida has planned, and Holden tells Alistair who he is in the real world.
Coulson and Jeffrey break into an Enlightenment Center to rescue a prisoner with valuable information about Project Looking Glass. Meanwhile, Fitz meets with an unexpected ally, and Jemma tries to convince Grant and Jeffrey that their world isn't real.
Daisy and Simmons uncover secrets and lies in a world gone mad. With Hydra in control, they become the only hope to save everyone.
Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.
The team follows a series of clues left by the Superior designed to bring them to their opponent's base... and the trap that he's set for them.
Daisy, Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman.
Coulson and the team race to save agents Sam and Bill Koenig from those trying to get their hands on the Darkhold book.
May races to find the truth. Aida's next move could mean the death of them all.
Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.
Though Coulson and May are growing closer, Coulson remains unaware of the dark secret May is hiding beneath the surface. Meanwhile, Aida is unrelenting in her search for the Darkhold.
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