Bana al-Abed has been offered a book deal by US publishers Simon and Schuster.
Source: Twitter/ AlabedBana
The seven-year-old's tweets of life inside the besieged city of Aleppo gave face to the human impact the Syrian war caused.
The Twitter account was managed by her mother Fatemah until last year, and has over 370,000 followers.
She now tweets from the account personally.
The book, titled Dear World, will be published in 2017.
"I am so happy to have this opportunity to tell my story and the story of what has happened in Aleppo to the world," Miss al-Abed said in a statement released by the publisher.
Miss al-Abed and her family were evacuated to Turkey in November, and she has since used her reach on Twitter to advocate for peace for Syria.