There will be no US Open matchup between Roger Federer and Rafael Nadal this year.
Federer's 18-match Grand Slam winning streak ended with a 7-5, 3-6, 7-6 (8), 6-4 quarter-final loss to Juan Martin del Potro.
The result prevented Federer and Nadal from meeting in the semi-finals, which would have been their first head-to-head showdown at Flushing Meadows.
It's the only major tournament where the longtime rivals have never faced each other.
Instead, it will be 2009 champion del Potro against two-time winner Nadal in Saturday's semi-finals.
The other semi-final is Pablo Carreno Busta against Kevin Anderson.
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