Federer has won the past three in a row, including an epic comeback in the Australian Open final two months ago.
Kyrgios defeated the three-time defending champion 6-4 7-6 (7-3) today to book a last-eight blockbuster with either Roger Federer or Rafael Nadal.
Kyrgios bowed out of his Marseille Open defence with a semi-final loss to Jo-Wilfried Tsonga but not without some customary fighting words.
"She's been there when I had no titles and she's still here 89 titles later," said Roger Federer.
Interrupting a 23-time grand slam champion with your ringtone after she's just won the Australian Open probably isn't the best way to get her attention.
The Swiss star narrowly missed a ball-kid with a wayward shot while playing Jo-Wilfred Tsonga.