Hurricanes first-five Beauden Barrett will miss out on Saturday's clash with the Chiefs in his home town of Taranaki due to a calf strain.
Replacing Barrett in the number ten jersey will be his Taranaki team-mate James Marshall.
Barrett had only just returned for the Hurricanes last week after a four week break, due to a knee injury.
While the Hurricanes will be without their All Black pivot their captain Conrad Smith will bring up an impressive milestone of 124 appearances for the Wellington-based Super Rugby franchise.
Smith achieved an earlier milestone this year when he and Nonu became the most capped midfield pairing for the Hurricanes and also passed Rodney So'oialo's record of being the most successful Hurricanes captain.
Hurricanes coach Chris Boyd has brought Mark Abbott, Callum Gibbons and Brad Shields into his starting side, opting to rest lock James Broadhurst.
Ardie Savea moves to the bench.
Wellington's blockbusting Nehe Milner-Skudder moves to fullback while the Hurricanes wider training group member Sam McNicol has been called into the reserves and could get his first Super Rugby start.