Wigan wore down a Toronto team without Sonny Bill Williams to win 32-10 in Sean O'Loughlin's 400th Super League game.
With Williams having flown back to New Zealand for the birth of his fourth child, the Wolfpack were left with just 17 fit players after former St Helens loose forward Jon Wilkin pulled out after the warm-up with a knee problem.
Despite the late change, Toronto scored first with the two teams level at 10-all after 58 minutes.
The Warriors scored four late tries to leave Toronto without a win after three games in Super League.
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