Liverpool have been handed a heavy defeat by Leicester City, after conceding three late goals in seven minutes.
Liverpool played well for 75 minutes at Leicester and led through Mo Salah's brilliantly-taken goal midway through the second half.
But seven minutes of madness turned the match on its head.
First, after Thiago gave away a free kick on the edge of the area - eventually confirmed by video review (VAR) - James Maddison fired the free kick into the net, a goal given by VAR after it was initially ruled out for offside against Daniel Amartey.
For the second match in succession, Liverpool goalkeeper Alisson then made a massive mistake in a mix-up with debutant defender Ozan Kabak, allowing Jamie Vardy to run in on an empty goal.
Harvey Barnes finished things off with a clinical third goal, leaving Liverpool with a third straight Premier League defeat, and for the champions' manager Jurgen Klopp to concede their title defence was over.
"I can't believe (the question), but yes," Klopp said, when asked if the title chase was over.
"I don't think we can close that gap this year.
"We are not worrying or whatever about the title, we are not silly. We have on Tuesday a tough game (away to RB Leipzig in the Champions League) and then on Saturday again, a derby.
"So these are the things we are thinking about. We want to have still a good season in the end, we have to win."
Leicester manager Brendan Rodgers was delighted with the win over his former club.
"It was a very good win, the players deserved it," he said.
"We didn't sink when we went a goal behind, we stayed calm and the players were brilliant in that period - a real collective team performance."
Meanwhile, Ilkay Gundogan continued his brilliant scoring streak as Manchester City beat Tottenham Hotspur 3-0 to go seven points clear at the top of the Premier League.
The Germany midfielder took his league tally to 11 goals, adding the second and third on Saturday after Rodri had put City ahead from the penalty spot to give his side a record-extending 16th straight win in all competitions.
It put City seven points ahead of Leicester, who moved above Manchester United into second after their win Liverpool.
At the Etihad, Gundogan won the penalty for Rodri to give City the lead on 23 minutes before adding the second and third goals in the 50th and 66th minutes, to leave Jose Mourinho's Tottenham still eighth.
City are now 13 points ahead of Liverpool, with a game in hand, a lead too big to chase down, according to the champions' manager.
Burnley moved up two places to 15th thanks to a 3-0 win at Crystal Palace with goals from Johann Berg Gudmundsson, Jay Rodriguez and Matthew Lowton, whose effort was stunning