Video: Jennifer Aniston's best friend attacks Angelina Jolie, claims 'she's a ****ing lunatic!'

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American comedian and TV personality Chelsea Handler has come out with her opinion on the divorce between Brad Pitt and Angelina Jolie - and it may be the most fiery one yet.

Handler, who is also known to be one of Jennifer Aniston's best friends, spoke about the power couple's split on her Netflix show where she called Jolie a "f***ing lunatic".

In the scathing monologue, Handler took multiple swipes at the actress and the lifestyle she led with Pitt.

"There are rumours that part of the problem was that Brad was allegedly drinking and smoking too much weed. I wonder why he would need to self-medicate," Handler said.

"Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages.

"Oh yeah, because he married a f***ing lunatic, that's why."

Pitt had previously been married to Aniston, but they divorced in 2005 after their marriage disintegrated shortly after Pitt met Jolie on the set of Mr & Mrs Smith.

Jolie filed for the divorce yesterday reportedly after she became "fed up" with Pitt's alleged drinking and use of recreational drugs, TMZ reports.

The pair were married in August 2014.

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